devortix.blogg.se

Professor Tim Spector OBE, lead scientist on the ZOE COVID Symptom Study app and Professor of Genetic Epidemiology at King’s said: “The data should reassure many people that in the real world, after effects of the vaccine are usually mild and short-lived, especially in the over 50’s who are most at risk of the infection. While rates of side effects were much lower than expected from clinical trials, rates of infection after vaccine were reassuring after two- three weeks and in line with findings from previous trials and recent data from the Israeli vaccination programme.

Similarly, in Phase III trials for the AstraZeneca vaccine, systemic side effects were found in 88% of younger participants (18-55 years) after the first dose but this study found a significantly lower rate of 46.2% after the first dose. In Phase III clinical trials of the Pfizer vaccine, the most common side effects were pain at the injection site (71-83%), fatigue (34-47%) and headache (25-42%), however the real-world analysis found less than 30% of users complained of injection site pain and less than 10% of fatigue and headache after the first dose. People with prior known COVID-19 infection were also more likely to experience local effects. Importantly, this research identifies that side effects were more common among people under 55 years of age and among women.Īlso, participants who had a confirmed case of prior COVID-19 were three times more likely to have side effects that effect the whole body after receiving doses of the Pfizer vaccine than those without known infection and almost twice more likely after the first dose of the AstraZeneca vaccine. The most common local side effect was tenderness: 57.2% and 50.9% after first and second dose of Pfizer vaccine, and 49.3% after first dose of AstraZeneca vaccine.8.4% and 14.4% of participants reported fatigue after first and second dose of Pfizer vaccine and 21.1% reported fatigue after their first dose of AstraZeneca vaccine. The second most reported systemic side effect was fatigue.22.8% of people who had the first dose of the AstraZeneca vaccine reported a headache. 7.8% of people reported suffering from headaches after the first Pfizer dose and 13.2% after the second Pfizer dose. The most reported systemic side effect was headache.13.5% of participants reported side effects after their first Pfizer dose, 22.0% after the second Pfizer dose and 33.7% after the first AstraZeneca dose.4% of vaccinated people indicated suffering from one or more systemic (excluding the area where the injection took place) side effects, whereas 66.2% reported one or more local (at injection site) side effects.The data comes from 627,383 users of the ZOE COVID Symptom Study app who self-reported systemic and local effects within eight days of receiving one or two doses of the Pfizer vaccine or one dose of the AstraZeneca vaccine between December 8 and March 10. Systemic effects - meaning side effects excluding where the injection took place - included headache, fatigue, chills and shiver, diarrhoea, fever, arthralgia, myalgia, and nausea whilst local side effects – meaning side effects where the injection took place in the arm – included pain at the site of injection, swelling, tenderness, redness, itch, warmth and swollen armpit glands. This large-scale analysis examined the differences of reported side effects from the two vaccines currently distributed in the UK. The drop in infection at least 21 days after the first dose for Pfizer is 69% and for AstraZeneca 60%.

The study also reports a significant decrease of infection rates from 12 to 21 days after the first dose of the Pfizer (58% reduction) and AstraZeneca (39% reduction) vaccines compared to a control group.

The analysis by researchers from King’s of data from the ZOE COVID Symptom Study app reassuringly found much fewer side effects in the general population with both the Pfizer and AstraZeneca vaccines than reported in trials. The study published today in the Lancet Infectious Diseases is the first large scale study to compare the two vaccines and investigate the prevalence of mild side effects of the UK’s vaccination programme.